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Genome Assemble & Annotation

De Novo Genome sequencing and assembly is the method of choice to resolve the genetic makeup of an uncharacterized genome for which no prior reference or nucleotide sequence exits. With its prodigious throughput, efficiency and high speed next-generation sequencing enables us to sequence whole genome at high coverage. Sophisticate and complex assembly algorithms are then applied to resolve the genomics sequence which reveals the gene structure and positioning.

Advantages Of Genome Assembly

There are several advantages that a resolved genome could provide:

  • Help study bacterial and fungal pathogenesis and virulence.
  • Genome annotation to build a genetic map.
  • Reveal various pathways operating in an organism.
  • Provide insights in evolutionary mechanism.
  • Validate experimental observations.
  • Help to understand structural variations and complex rearrangements like insertions, inversion, translocation and copy number variations.
  • Characterization of alternative splicing and study gene expression levels.

Genome assembly could be classified into two types:

  • Reference-based assembly:
    – Assess quality of sequencing (re-sequencing)
    – Identify and annotate novel features, etc.
  • De novo assembly:
    – generate reference
    – Identify novel features
    – Annotate existing but un-annotated features

A typical genome assembly workflow is displayed, these steps make use of various bioinformatics tools and algorithm to generate final genome assembly and annotation.

Our Comprehensive Approach: Analyzing Both Short and Long Reads

At 1010Genome, we understand that genomics is a multi-dimensional puzzle, and to solve it, you need the right pieces. That's why we offer a comprehensive suite of genome assembly analysis, including analysis of both short and long reads. We work across various platforms, making sure you have access to the most advanced sequencing technologies available.

Short-Read Next-Generation Sequencing: Illumina and Ion Torrent Platforms

Short-read sequencing is a powerhouse for generating vast amounts of data quickly and cost-effectively. Whether you're conducting large-scale population studies, identifying variations, or studying gene expression, our expert team at 1010Genome is well-equipped to handle data generated by Illumina and Ion Torrent platforms. We'll ensure that your short-read data is processed with precision, delivering you reliable insights.

DNA Sequencing Services

Long-Read Next-Generation Sequencing: Pacific Biosciences and Oxford Nanopore Technologies

Sometimes, the intricacies of the genome require a more detailed examination, which is where long-read sequencing comes into play. With Pacific Biosciences and Oxford Nanopore Technologies, we delve deep into structural variations, resolving complex genomic regions, and providing a finer level of detail. Our long-read analysis services enable you to tackle the most challenging genomic questions with confidence.

The 1010Genome Advantage

Our genome assembly services are designed to accommodate various project scopes, from microbial genomes to complex eukaryotic genomes. Whether you're exploring the genetic diversity of a species, deciphering the secrets of a microbial community, or unraveling the mysteries of a human genome, we have the expertise and technology to assist you.

Our genome assembly services cover a wide range of applications, including:

  • De Novo Genome Assembly: Constructing a genome from scratch, without a reference sequence.
  • Reference-Based Genome Assembly: Aligning short sequence reads to a known reference genome, useful for comparative genomics.
  • Metagenome Assembly: Reconstructing the genomes of microorganisms from complex environmental or microbiome samples.
  • Eukaryotic and Prokaryotic Genomes: We're equipped to handle the assembly of both simple prokaryotic genomes and complex eukaryotic genomes.
  • Customized Solutions: No two genomes are the same, and we recognize that your project is unique. We tailor our genome assembly services to meet your specific needs, providing solutions that align seamlessly with your research objectives.
  • Comprehensive Genome Coverage: Our assembly process is designed to capture the full scope of the genome, leaving no genetic region unexplored. We aim to provide you with a holistic understanding of the genetic makeup of your subject.
  • Cost-Effectiveness: We are committed to providing cost-effective genome assembly services without compromising on quality. We understand that budgets can be a constraint, and we strive to offer you the best value for your investment.
  • Timely Results: We appreciate the importance of meeting deadlines in research projects. Our streamlined processes ensure that you receive your assembly results promptly.

Unlock the power of complete genomes and embark on a journey of discovery with 1010Genome.

Transform your research, clinical diagnostics, and genetic insights with 1010Genome's Genome Assembly Services. Our world-class team, cutting-edge technology, and tailored solutions are your path to unlocking the complete genetic blueprint. Take the next step in your genomics journey.

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